Comparative In Vitro Quality Assessment of Five Brands of Furosemide Tablets Marketed in Port Harcourt, Nigeria
Background: Medication failure, high morbidity and mortality resulting from the circulation and consumption of
fake, adulterated and substandard medicines have been a worrisome issue to health practitioners, patients and drug
regulatory agencies of Nigeria.
Objective: This study aims at evaluating some brands of furosemide tablets that are marketed in Port Harcourt,
Nigeria to know if they meet with their label claims and British Pharmacopoeia (BP) or the United States
Pharmacopoeia (USP) set limits for such products.
Materials and Methods: Five brands of furosemide tablets marketed in Nigeria were randomly collected from
different retail pharmacy outlets and investigated for uniformity of tablet weight, disintegration, friability, hardness,
and drug release profile using standard methods. Two assay methods based on titrimetry and spectrophotometry
were employed for the determination of the content of furosemide in the tablet formulations or its bulk drug.
Results: Results obtained showed tablet weight in the range of 174 mg ± 0.05% to 274 mg ± 0.01 %, hardness
ranging from 3.20 ± 0.01 to 10.70 ± 1.70 kg/F, friability of < 1 %, disintegration time of 5.20 ± 0.88 to 9.30 ± 0.50
min, drug release of > 80 % within 30 min and assay of 86.45 to 100.80 % .
Conclusion: Most of the tablet batches tested met with label claim in terms of the content of furosemide and also
complied with acceptance limits of the British Pharmacopoeia (BP) or the United States Pharmacopoeia (USP) and
were adjudged to be of good quality.
Keywords: Furosemide, active pharmaceutical ingredient, British Pharmacopoeia, United States Pharmacopoeia
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