Evaluation of CD4 Count Progression in HIV-Infected Patients on Different Classes of Antiretroviral Regimens

  • A A BIAMBO
  • A SAMAILA
  • N USMAN
  • H M LIMAN

Abstract

Background: Understanding the expected effects of different antiretroviral regimens on CD4 count will guide therapeutic decision and monitoring treatment progress that will improve patients’ outcomes.
Objective: To evaluate the effects of two first line and one second line antiretroviral regimens on annual changes in CD4 count of HIV-infected patients at Usmanu Danfodiyo University Teaching Hospital, Sokoto.
Method: A retrospective analysis of patients’ records between 2011 and 2015 which were selected using systematic random sampling was conducted. A total of 423 records of patients that met the inclusion criteria were evaluated for changes in CD4 count. The data were analysed using descriptive, correlation and linear regression statistics, with p<0.05 considered statistically significant.
Results: Majority of the patients were females (75.4%) and their mean age was 37.1±9.1 years. Correlation analysis showed that increasing duration of the disease state (p=0.001) and treatment (p=0.001) were significantly associated with low annual percentage increase in CD4 count. Linear regression models showed that among patients with CD4 cell counts of ≤300 cells/mm3, the annual percentage increase of those on Tenofovir (TDF) + Emtricitabine (or Lamivudine) (XTC) + Efavirenz (EFZ), Zidovudine (AZT) + Lamivudine (3TC) + Nevirapine (NVP)and TDF+XTC + Lopinavir/ritonavir (LPV/r) regimens were 41.1%, 16.9% and 4.9% respectively. Patients with CD4 counts >300 to 500 cells/mm3 mostly had insignificant increase of 4.5%, 1.3% and 2.9% respectively. All patients with CD4 >500 cells/mm3 had insignificant decrease.
Conclusion: Significant increase in annual percentage CD4 count is observed only when the CD4 count is low with patients on TDF+XTC+EFZ regimen showing the best increase. Increase in duration of the disease and treatment were associated with low annual increase.
Keywords: Antiretroviral regimen, CD4 count, HIV, Highly active antiretroviral therapy

Published
2019-07-14
How to Cite
BIAMBO, A A et al. Evaluation of CD4 Count Progression in HIV-Infected Patients on Different Classes of Antiretroviral Regimens. Nigerian Journal of Pharmaceutical Research, [S.l.], v. 15, n. 1, p. 19-26, july 2019. ISSN 2635-3555. Available at: <http://nigjpharmres.com/ojs/index.php/NigJPharmRes/article/view/109>. Date accessed: 18 oct. 2019.
Section
Articles

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